Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol depletes glutathione your livers most important protective antioxidant. Every dose chips away at it., So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 Taking Tylenol? The Glutathione Connection Dr. Green Mom Glutathione IV for Liver Detox: Support & Benefits AZ IV Medics Is Tylenol Bad for Your Liver or Kidneys? GoodRx